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The liver X receptors, LXRalpha and LXRbeta, were originally identified as orphan nuclear receptors and then demonstrated to be essential mediators in the activation of the transcription of genes involved in cholesterol metabolism. However, LXRs are now known to be important players in cell signaling in an array of endocrine and metabolic cell types, including steroidogenic cells. Here, we review recent work that defines the role of LXRs in regulation of steroidogenesis and lipid homeostasis in pituitary gonadotropes, theca cells, adrenocortical cells, and adrenocortical tumors. We also discuss the roles of LXRs in other metabolic tissues and the current status of LXR agonism in the clinic.A longitudinal study of vasculitis: the University of Texas System Health Science Center GI and liver clinic experience.
To describe our longitudinal experience with systemic vasculitis. Retrospective review of patient records at The University of Texas Health Science Center (UTHealth) GI and liver clinic. The UTHealth GI and liver clinic provides comprehensive care for patients with vasculitis. The clinic represents a longitudinal study of patients followed at 4 time points. From 2001 through 2010, 984 patients were seen. Etiologies were vasculitis in 52.7% of the patients; of those, 23.5% were classified as systemic. Most patients (72.8%) received a systemic diagnosis of vascul