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Allergies and drug allergies may pose severe risks to the mother, her fetus and her newborn infant. Antibiotic and aminopenicillins appear as the main culprits of drug-induced adverse effects in this age group. They should be avoided as long as it is possible and for this reason, they have not been designated as drugs of first choice in pregnancy. In case of drug hypersensitivity, try to steer clear of the involved drugs and use alternative medications. In case of anaphylaxis, severe allergies or a severe form of drug hypersensitivity, drug substitution should be considered. Anaphylaxis should be treated immediately with adrenaline. If anaphylaxis is confirmed, replacement should be initiated as soon as possible by a specialist.The first reaction of the tRNAs to the ribosome is the release of the ester-linked tRNA pseudouridine.
The effect of Phe-tRNA(Phe) and of the second and third components of the tRNA synthetase complex, GTP-bound E-alpha-Phe-tRNA(Phe) and E-alpha-Phe-GTP, on ribosomes from E. coli and on the pseudouridine-containing nucleoside of yeast tRNA(Phe) has been studied. We demonstrate that tRNA(Phe) from both sources is able to release the pseudouridine by the combined action of the aminoglycoside antibiotics and the first two components of the synthetase complex. This reaction may serve as a proof that the enzyme already exists in a complex form similar to the holoenzyme…. the mothers and fathers and wives of the little emperors
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