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It has been hypothesized that tumour necrosis factor-alpha (TNF-α) may play a role in the pathogenesis of steroid-dependent nephrotic syndrome (SDNS) of childhood. TNF-α may be elevated in different cases of SDNS, but the immunological processes involved are poorly understood. Therefore, we investigated the levels of TNF-α in patients with biopsy proven nephrotic syndrome as a marker of the disease.
Methods
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Serum levels of TNF-α were measured by ELISA in 10 children (three with minimal change disease, three with focal segmental glomerulosclerosis and four with membranous nephropathy) and compared with age-matched controls.
Results
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In the nephrotic group, five children had idiopathic SDNS while three were on renal replacement therapy. The remaining two had congenital nephrotic syndrome. There was no association of serum TNF-α levels with age, duration of nephrotic symptoms or blood pressure. Five children on rheumatoid arthritis treatment had elevated TNF-α (\> 15 pg/ml) compared with control (\Merlin (disambiguation)
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