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Glioblastoma (GBM) is the most common and deadly type of primary brain tumor with no effective treatment currently available. Recently, reintroduction of the transcription factor HoxA9 into glioma cells sensitized them to apoptosis by upregulating the expression of the tumor suppressor gene p53. This has opened the door to the potential use of HoxA9 in the treatment of human gliomas. The purpose of this study is to evaluate the efficacy of the delivery system based on the protein transduction domain (PTD) derived from the HIV-Tat protein and a human telomerase reverse transcriptase (hTERT) promoter to drive HoxA9 expression in human glioma cells (U87 and U118). The efficacy of this therapy will be assessed by measuring apoptosis and cell growth inhibition of these
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